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They have been characterized previously and express the GLP-1R at 1 pmol/mg total cellular protein with a K d for GLP-1 736 amide of 1 nM [7]

A 2024 review recognized AOD-9604 among key peptides showing promise for cartilage regeneration in osteoarthritis, though the authors note that more research, particularly in human subjects, is needed to establish clinical efficacy